What Is Prednisone Used for in Dogs? Prednisone is a powerful anti-inflammatory, immunosuppressant and anti-itch medication. Dr. Kelly Dunham, D.V.M., and area medical director for IndeVets, a Prednisone Dosage For Dogs. The dosage of prednisone for prednisolone for dogs will vary depending on the condition being treated, their body weight, and their response to treatment. When prednisone is used as a replacement hormone to treat Addison’s disease, it is generally used at a very low dose. What is prednisone used for in dogs? Considering the functions of cortisol, you may be able to figure out some of the reasons a vet might prescribe prednisone for your dog. 1. Prednisone for dogs is used as an anti-inflammatory drug. Any type of tissue in a dog’s body may become inflamed for one reason or another. 98Jg4m.